ANKS3

Across TCGA patient cohorts, ANKS3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKS3-associated genes across cancer lineages are EGFR_pY1173, Caspase-7-cleavedD198, and 53BP1. Each is linked with ANKS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKS3-to-partner and partner-to-ANKS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by ANKS3-low versus ANKS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKS3→partner) and Y-score (partner→ANKS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.068	+1.833	.040	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.794	+2.604	.001	.005	3	2
SKCM	53BP1 →	+0.430	+3.169	.035	.019	3	1
UCEC	ERK2 →	+0.202	+2.459	.011	.019	3	1
UCEC	GAPDH →	+0.436	+2.999	.049	.035	3	1
UCEC	HER3_pY1289 →	+0.091	+3.479	.010	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

EGFR_pY1173 by ANKS3 expression — UCEC

Explore this box plot interactively →