ANKS3

Across TCGA cell cohorts, ANKS3 mutation is significantly associated with the RNA expression of many other genes, with 787 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANKS3-associated genes across cancer lineages are SLCO1B7, GAGE12J, and MDFIC2. Each is linked with ANKS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKS3-to-partner and partner-to-ANKS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLCO1B7 grouped by ANKS3-low versus ANKS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKS3→partner) and Y-score (partner→ANKS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLCO1B7 →	+1.232	+3.364	<.001	.002	3	2
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MDFIC2 →	+0.026	+4.643	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.170	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	MS4A10 →	+0.011	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	USP17L22 →	+0.010	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 787 associations by consensus.

SLCO1B7 by ANKS3 expression — LARGE_INTESTINE

Explore this box plot interactively →