ANKS1A

Across TCGA patient cohorts, ANKS1A mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKS1A-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and STAT3_pY705. Each is linked with ANKS1A in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKS1A-to-partner and partner-to-ANKS1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ANKS1A-low versus ANKS1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKS1A→partner) and Y-score (partner→ANKS1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.659	+1.867	<.001	.004	3	3
UCEC	Cyclin-B1 →	+0.600	+2.321	<.001	.005	3	3
SKCM	STAT3_pY705 →	-0.313	-3.584	.016	.002	2	3
COAD	eIF4E →	+0.194	+2.347	.016	.019	3	2
UCEC	p70-S6K_pT389 →	-0.126	-1.700	.032	.040	3	2
UCEC	PCNA →	+0.189	+1.643	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Caspase-7-cleavedD198 by ANKS1A expression — UCEC

Explore this box plot interactively →