ANKS1A

Across TCGA cell cohorts, ANKS1A mutation is significantly associated with the RNA expression of many other genes, with 223 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ANKS1A-associated genes across cancer lineages are MMP26, MBD3L2, and HIPK4. Each is linked with ANKS1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKS1A-to-partner and partner-to-ANKS1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by ANKS1A-low versus ANKS1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKS1A→partner) and Y-score (partner→ANKS1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MMP26 →	+0.033	+3.217	<.001	.006	3	2
CNS	MBD3L2 →	+1.117	+4.981	.001	.008	3	2
BLOOD_Leukemia	HIPK4 →	+0.048	+3.619	<.001	.001	3	2
BLOOD_Leukemia	HIGD2B →	+0.046	+3.560	<.001	<.001	3	2
BLOOD_Leukemia	KCNK4 →	+0.153	+2.783	<.001	.001	3	2
BLOOD_Lymphoma	CST5 →	+0.532	+5.209	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 223 associations by consensus.

MMP26 by ANKS1A expression — LARGE_INTESTINE

Explore this box plot interactively →