ANKRD9

Across TCGA pan-cancer cohorts, ANKRD9 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ANKRD9’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ANKRD9 RNA is repressed in tumor relative to normal tissue. In most cancer types ANKRD9 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and COAD are the cancer types where ANKRD9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKRD9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−2.202	<.001	11	view →
KIRC	Male	II,III,IV	−1.616	<.001	11	view →
COAD	All	III,IV	−1.020	<.001	11	view →
LIHC	Female	II,III,IV	+1.541	<.001	9	view →
UCEC	All	All	+0.860	<.001	6	view →
KIRP	Male	All	−0.834	<.001	6	view →
KICH	Female	II,III,IV	+1.737	<.001	5	view →
CHOL	Male	All	+1.580	<.001	5	view →
HNSC	All	II,III,IV	+0.429	.005	5	view →
LUAD	All	All	−0.399	<.001	5	view →
LUSC	Male	III,IV	+1.357	.003	2	view →
STAD	Male	IV	+0.959	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ANKRD9–THCA

Open the THCA breakdown →