ANKRD66

Across TCGA patient cohorts, ANKRD66 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD66-associated genes across cancer lineages are 14-3-3_beta, HSP70, and P-Cadherin. Each is linked with ANKRD66 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD66-to-partner and partner-to-ANKRD66 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ANKRD66-low versus ANKRD66-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD66→partner) and Y-score (partner→ANKRD66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.163	-3.308	.001	.010	3	1
UCEC	HSP70 →	-0.552	-3.321	.008	.010	3	1
UCEC	P-Cadherin →	-0.158	-2.999	.037	.035	3	1
UCEC	ATM →	-0.542	-3.321	.022	.010	3	1
UCEC	Di-Ras3 →	-0.210	-3.321	.006	.010	3	1
UCEC	Heregulin →	-0.150	-3.321	.020	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

14-3-3_beta by ANKRD66 expression — UCEC

Explore this box plot interactively →