ANKRD65

Across TCGA pan-cancer cohorts, ANKRD65 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ANKRD65 data layer compared with 1 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ANKRD65 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ANKRD65 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UVM show a favorable association.

LUAD, UVM, and HNSC are the cancer types where ANKRD65 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.762	0.607	<.001	104	view →
UVM	DFS	Median	All	0.738	0.408	<.001	78	view →
HNSC	DFS	Tertile	III,IV	0.505	0.278	.002	61	view →
KICH	OS	Median	All	1.000	0.753	.002	56	view →
KIRC	DFS	Tertile	All	0.724	0.548	<.001	40	view →
LGG	DFS	Median	All	0.661	0.807	<.001	39	view →
SCLC	DFS	Quartile	II,III,IV	0.632	0.244	.004	28	view →
LUSC	OS	Median	II,III,IV	0.813	0.671	.003	25	view →
LAML	DFS	Quartile	All	0.260	0.534	.005	18	view →
MESO	OS	Tertile	All	0.245	0.620	.026	13	view →
CESC	DFS	Quartile	IV	0.781	0.311	.013	12	view →
ACC	OS	Quartile	II,III,IV	0.193	0.864	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ANKRD65–LUAD (OS)

Open the LUAD breakdown →