ANKRD54

Across TCGA pan-cancer cohorts, ANKRD54 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ANKRD54 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ANKRD54 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ANKRD54 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where ANKRD54 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.745	0.955	<.001	38	view →
LUAD	DFS	Tertile	All	0.803	0.993	.001	24	view →
CCRCC	DFS	Quartile	II,III,IV	0.887	0.198	.024	10	view →
PDAC	OS	Quartile	III,IV	0.321	0.979	.010	10	view →
GBM	OS	Median	All	0.544	0.269	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ANKRD54–LSCC (OS)

Open the LSCC breakdown →