ANKRD53

Across TCGA patient cohorts, ANKRD53 mutation is significantly associated with the RNA expression of many other genes, with 1,877 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD53-associated genes across cancer lineages are TRAJ21, DUTP8, and RPL23AP82. Each is linked with ANKRD53 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD53-to-partner and partner-to-ANKRD53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ21 grouped by ANKRD53-low versus ANKRD53-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD53→partner) and Y-score (partner→ANKRD53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ21 →	+0.889	+2.823	<.001	.006	3	2
COAD	DUTP8 →	+0.180	+2.799	<.001	.004	3	2
UCEC	RPL23AP82 →	+0.375	+2.332	.001	<.001	3	2
UCEC	TRAPPC4 →	+0.395	+2.364	.001	<.001	3	2
UCEC	SRA1 →	+0.251	+2.818	.009	.001	3	2
UCEC	RPL17P50 →	+0.403	+3.480	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,877 associations by consensus.

TRAJ21 by ANKRD53 expression — COAD

Explore this box plot interactively →