ANKRD53

Across TCGA cell cohorts, ANKRD53 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ANKRD53-associated genes across cancer lineages are TPD52L3, LCE1C, and SLC5A8. Each is linked with ANKRD53 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD53-to-partner and partner-to-ANKRD53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPD52L3 grouped by ANKRD53-low versus ANKRD53-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD53→partner) and Y-score (partner→ANKRD53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TPD52L3 →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1
BLOOD_Lymphoma	TUSC1 →	+0.936	+3.579	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TPD52L3 by ANKRD53 expression — BLOOD_Leukemia

Explore this box plot interactively →