ANKRD50

Across TCGA pan-cancer cohorts, ANKRD50 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ANKRD50 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ANKRD50 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ANKRD50 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

LSCC, LUAD, and UCEC are the cancer types where ANKRD50 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.658	0.911	.004	38	view →
LUAD	DFS	Tertile	All	0.808	0.963	.004	9	view →
UCEC	DFS	Tertile	II,III,IV	0.900	0.510	.032	4	view →
CCRCC	DFS	Median	All	0.915	0.647	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ANKRD50–LSCC (DFS)

Open the LSCC breakdown →