ANKRD49

Across TCGA pan-cancer cohorts, ANKRD49 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ANKRD49’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ANKRD49 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ANKRD49 is over-expressed in tumor, although a few such as PDAC and LUAD show the opposite, repressed pattern.

CCRCC, PDAC, and LUAD are the cancer types where ANKRD49 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKRD49 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.545	<.001	10	view →
PDAC	All	All	−0.568	<.001	8	view →
LUAD	Male	All	−0.276	<.001	3	view →
LSCC	Female	III,IV	+0.290	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ANKRD49–CCRCC

Open the CCRCC breakdown →