Across TCGA patient cohorts, ANKRD45 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD45-associated genes across cancer lineages are p90 RSK, PRAS40_pT246, and STAT3_pY705. Each is linked with ANKRD45 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD45-to-partner and partner-to-ANKRD45 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD45→partner) and Y-score (partner→ANKRD45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p90 RSK →	+0.259	+3.321	.001	.009	3	2
SKCM	PRAS40_pT246 →	-0.138	-2.309	.025	.033	3	2
UCEC	STAT3_pY705 →	-0.366	-2.311	.002	.034	3	2
SKCM	NF-kB-p65_pS536 →	-0.345	-2.000	.023	.029	3	1
SKCM	N-Ras →	+0.114	+1.874	.033	.047	3	1
SKCM	Akt_pS473 →	-0.484	-2.000	.022	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

ANKRD45 survival (RNA) · tumor vs normal (RNA) · all ANKRD45 data types