ANKRD33

Across TCGA pan-cancer cohorts, ANKRD33 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ANKRD33’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ANKRD33 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANKRD33 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

LUSC, COAD, and BRCA are the cancer types where ANKRD33 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKRD33 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	+0.094	.007	6	view →
COAD	All	II,III,IV	+0.090	<.001	6	view →
BRCA	All	II,III,IV	−0.037	<.001	6	view →
LIHC	All	All	+0.331	.004	5	view →
KIRC	All	All	+0.094	.003	5	view →
READ	All	All	+0.117	.004	2	view →
KIRP	Female	II,III,IV	+0.066	.043	2	view →
LUAD	All	All	+0.025	.010	2	view →
HNSC	All	II,III,IV	+0.017	.033	2	view →
STAD	All	All	+0.136	.038	1	view →
CHOL	Male	All	+0.075	.013	1	view →
THCA	All	All	+0.019	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ANKRD33–LUSC

Open the LUSC breakdown →