ANKRD23

Across TCGA patient cohorts, ANKRD23 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD23-associated genes across cancer lineages are FOXO3a_pS318_S321, MAPK_pT202_Y204, and NF2. Each is linked with ANKRD23 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD23-to-partner and partner-to-ANKRD23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by ANKRD23-low versus ANKRD23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD23→partner) and Y-score (partner→ANKRD23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.171	-3.169	.004	.018	3	1
UCEC	MAPK_pT202_Y204 →	-0.549	-3.000	.015	.036	3	1
UCEC	NF2 →	+0.313	+2.459	.002	.020	3	1
UCEC	PKC-delta_pS664 →	-0.148	-3.169	.010	.018	3	1
UCEC	Annexin-1 →	+0.758	+3.189	.002	.010	3	1
UCEC	RBM15 →	+0.306	+2.820	.047	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

FOXO3a_pS318_S321 by ANKRD23 expression — UCEC

Explore this box plot interactively →