ANKRD22

Across TCGA patient cohorts, ANKRD22 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD22-associated genes across cancer lineages are Gab2, INPP4B, and JNK_pT183_Y185. Each is linked with ANKRD22 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD22-to-partner and partner-to-ANKRD22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by ANKRD22-low versus ANKRD22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD22→partner) and Y-score (partner→ANKRD22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.455	+2.321	.011	.035	3	1
UCEC	INPP4B →	-0.334	-3.169	.039	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.197	-2.308	.019	.036	3	1
UCEC	JNK2 →	+0.263	+3.009	.008	.019	3	1
UCEC	Ku80 →	+0.365	+3.472	.002	.002	3	1
UCEC	PCNA →	+0.283	+3.459	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Gab2 by ANKRD22 expression — UCEC

Explore this box plot interactively →