ANKRD2

Across TCGA patient cohorts, ANKRD2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD2-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and JNK2. Each is linked with ANKRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD2-to-partner and partner-to-ANKRD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ANKRD2-low versus ANKRD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD2→partner) and Y-score (partner→ANKRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.749	+2.604	.002	.005	3	2
UCEC	FoxM1 →	+0.314	+3.321	.004	.009	3	1
UCEC	JNK2 →	+0.256	+3.179	.002	.010	3	1
UCEC	MEK1 →	+0.581	+2.906	<.001	.001	3	1
UCEC	Notch1 →	+0.167	+2.222	.005	.011	3	1
UCEC	Smad4 →	+0.128	+2.341	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Caspase-7-cleavedD198 by ANKRD2 expression — UCEC

Explore this box plot interactively →