ANKRD17

Across TCGA pan-cancer cohorts, ANKRD17 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ANKRD17’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ANKRD17 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ANKRD17 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

HNSC, CCRCC, and LSCC are the cancer types where ANKRD17 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKRD17 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.224	<.001	11	view →
CCRCC	All	III,IV	−0.102	<.001	10	view →
LSCC	Male	All	+0.409	<.001	9	view →
LUAD	Female	III,IV	+0.385	<.001	9	view →
COAD	All	III,IV	+0.251	<.001	9	view →
PDAC	All	All	−0.123	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ANKRD17–HNSC

Open the HNSC breakdown →