ANKRD17

Across TCGA cell cohorts, ANKRD17 mutation is significantly associated with the RNA expression of many other genes, with 766 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANKRD17-associated genes across cancer lineages are HSD17B6, SMIM14, and CRBN. Each is linked with ANKRD17 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKRD17-to-partner and partner-to-ANKRD17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSD17B6 grouped by ANKRD17-low versus ANKRD17-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD17→partner) and Y-score (partner→ANKRD17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSD17B6 →	+1.004	+3.321	<.001	.002	3	3
LUNG_NSCLC_LUAD	SMIM14 →	+1.146	+3.621	.001	<.001	3	3
CNS	CRBN →	+0.472	+2.528	.001	.006	3	2
CNS	HTR5A →	+0.014	+2.209	.001	.006	3	2
LARGE_INTESTINE	L3MBTL2 →	+0.547	+2.459	.002	.003	3	2
LARGE_INTESTINE	MAPK8 →	+0.689	+2.215	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 766 associations by consensus.

HSD17B6 by ANKRD17 expression — LARGE_INTESTINE

Explore this box plot interactively →