ANKRD16

Across TCGA patient cohorts, ANKRD16 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD16-associated genes across cancer lineages are EGFR_pY1068, Myosin-IIa_pS1943, and Caspase-7-cleavedD198. Each is linked with ANKRD16 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD16-to-partner and partner-to-ANKRD16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ANKRD16-low versus ANKRD16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD16→partner) and Y-score (partner→ANKRD16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.252	-2.584	.031	.011	3	2
UCEC	Myosin-IIa_pS1943 →	+0.289	+2.598	.002	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.728	+3.169	.008	.018	3	2
UCEC	MEK1 →	+0.445	+3.169	.009	.019	3	1
UCEC	Myosin-IIa →	+0.232	+2.592	.007	.006	3	1
UCEC	Notch1 →	+0.188	+3.009	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by ANKRD16 expression — UCEC

Explore this box plot interactively →