ANKRD12

Across TCGA patient cohorts, ANKRD12 mutation is significantly associated with the RNA expression of many other genes, with 4,993 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD12-associated genes across cancer lineages are MRPL54, CHAF1A, and FCER1A. Each is linked with ANKRD12 in more than 4 cancer types. Because this analysis shows association rather than direction, both ANKRD12-to-partner and partner-to-ANKRD12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL54 grouped by ANKRD12-low versus ANKRD12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD12→partner) and Y-score (partner→ANKRD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL54 →	+0.312	+2.362	.004	<.001	3	5
UCEC	CHAF1A →	+0.672	+2.413	<.001	<.001	3	5
UCEC	FCER1A →	-0.677	-2.000	<.001	<.001	3	4
UCEC	SREBF2-AS1 →	+0.428	+1.949	<.001	<.001	3	4
UCEC	PTP4A3 →	-0.772	-2.000	<.001	<.001	3	4
STAD	CIAO2B →	+0.564	+3.207	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,993 associations by consensus.

MRPL54 by ANKRD12 expression — UCEC

Explore this box plot interactively →