ANKRD12

Across TCGA patient cohorts, ANKRD12 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD12-associated genes across cancer lineages are Cyclin-B1, eIF4E, and PCNA. Each is linked with ANKRD12 in more than 3 cancer types. Because this analysis shows association rather than direction, both ANKRD12-to-partner and partner-to-ANKRD12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ANKRD12-low versus ANKRD12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD12→partner) and Y-score (partner→ANKRD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.588	+2.662	<.001	<.001	3	4
COAD	eIF4E →	+0.222	+2.347	.005	.019	3	3
COAD	PCNA →	+0.370	+3.012	<.001	.018	3	3
COAD	ATM →	-0.689	-3.000	<.001	.034	3	3
UCEC	PDCD4 →	-0.372	-1.206	.004	.009	3	3
UCEC	STAT3_pY705 →	-0.405	-1.917	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Cyclin-B1 by ANKRD12 expression — UCEC

Explore this box plot interactively →