ANKRD12

Across TCGA cell cohorts, ANKRD12 mutation is significantly associated with the RNA expression of many other genes, with 751 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANKRD12-associated genes across cancer lineages are PRDM4, NBL1, and RPRD1B. Each is linked with ANKRD12 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKRD12-to-partner and partner-to-ANKRD12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDM4 grouped by ANKRD12-low versus ANKRD12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD12→partner) and Y-score (partner→ANKRD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRDM4 →	+0.465	+3.321	.002	.003	3	3
BLOOD_Leukemia	NBL1 →	+1.194	+3.260	.005	.005	3	3
BLOOD_Leukemia	RPRD1B →	+0.393	+2.614	.007	.003	3	2
LARGE_INTESTINE	PLEKHA3 →	+0.753	+3.137	<.001	.007	3	2
BLOOD_Leukemia	SMU1 →	+0.357	+3.730	.007	<.001	2	3
BLOOD_Leukemia	LBX1 →	+0.002	+2.362	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 751 associations by consensus.

PRDM4 by ANKRD12 expression — LARGE_INTESTINE

Explore this box plot interactively →