ANKRA2

Across TCGA patient cohorts, ANKRA2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRA2-associated genes across cancer lineages are p21, p62 Lck ligand, and CDK1_pY15. Each is linked with ANKRA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRA2-to-partner and partner-to-ANKRA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by ANKRA2-low versus ANKRA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRA2→partner) and Y-score (partner→ANKRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.232	+2.820	.021	.035	3	1
UCEC	p62 Lck ligand →	+0.475	+3.009	.005	.019	3	1
UCEC	CDK1_pY15 →	+0.216	+2.191	.048	.034	3	1
UCEC	Chk1_pS345 →	+0.173	+2.183	.016	.035	3	1
UCEC	INPP4B →	-0.453	-3.169	.007	.019	2	1
UCEC	MEK1 →	+0.576	+3.169	.002	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

p21 by ANKRA2 expression — UCEC

Explore this box plot interactively →