ANKMY1

Across TCGA patient cohorts, ANKMY1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKMY1-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and IGFBP2. Each is linked with ANKMY1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ANKMY1-to-partner and partner-to-ANKMY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ANKMY1-low versus ANKMY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKMY1→partner) and Y-score (partner→ANKMY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.589	+2.321	.002	.005	3	4
UCEC	4E-BP1 →	+0.373	+3.807	<.001	<.001	3	3
STAD	IGFBP2 →	+0.588	+2.459	.030	.019	3	2
UCEC	ATM →	-0.652	-2.571	<.001	<.001	3	2
COAD	INPP4B →	-0.561	-3.576	<.001	.002	3	2
COAD	PARP_cleaved →	+0.561	+3.182	.015	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by ANKMY1 expression — UCEC

Explore this box plot interactively →