ANKLE2

Across TCGA cell cohorts, ANKLE2 mutation is significantly associated with the RNA expression of many other genes, with 933 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANKLE2-associated genes across cancer lineages are GALR3, ADAD1, and KNCN. Each is linked with ANKLE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKLE2-to-partner and partner-to-ANKLE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALR3 grouped by ANKLE2-low versus ANKLE2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKLE2→partner) and Y-score (partner→ANKLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GALR3 →	+0.112	+3.799	<.001	.003	3	2
LUNG_NSCLC_LUAD	ADAD1 →	+0.031	+2.786	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	KNCN →	+0.023	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	DEFB132 →	+0.006	+4.736	<.001	.009	3	2
LARGE_INTESTINE	USP14 →	+0.784	+3.546	<.001	<.001	3	2
LARGE_INTESTINE	CLUAP1 →	+0.608	+3.082	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 933 associations by consensus.

GALR3 by ANKLE2 expression — SOFT_TISSUE

Explore this box plot interactively →