ANKLE1

Across TCGA pan-cancer cohorts, ANKLE1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ANKLE1 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ANKLE1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ANKLE1 expression acts as an unfavorable survival marker.

BLCA, STAD, and SKCM are the cancer types where ANKLE1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.195	0.720	.003	18	view →
STAD	OS	Median	II,III,IV	0.242	0.678	.026	6	view →
SKCM	OS	Median	III,IV	0.238	0.729	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ANKLE1–BLCA (OS)

Open the BLCA breakdown →