ANKLE1

Across TCGA patient cohorts, ANKLE1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKLE1-associated genes across cancer lineages are DJ-1, ATM, and Rb. Each is linked with ANKLE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKLE1-to-partner and partner-to-ANKLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DJ-1 grouped by ANKLE1-low versus ANKLE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKLE1→partner) and Y-score (partner→ANKLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DJ-1 →	+0.177	+2.000	.018	.032	3	3
UCEC	ATM →	-0.569	-2.700	.005	.006	3	2
SKCM	Rb →	+0.211	+3.000	.021	.036	3	1
UCEC	eIF4E →	+0.198	+3.169	.037	.019	2	2
UCEC	IGFBP2 →	-0.633	-2.000	.030	.032	3	1
UCEC	MEK1 →	+0.428	+2.700	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

DJ-1 by ANKLE1 expression — UCEC

Explore this box plot interactively →