ANKLE1

Across TCGA cell cohorts, ANKLE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,538 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ANKLE1-associated GO terms across cancer lineages are Regulation of myeloid progenitor cell differentiation, Nucleolar large rRNA transcription by RNA polymerase I, and rRNA metabolic process. Each is linked with ANKLE1 in more than 16 cancer types. Because this analysis shows association rather than direction, both ANKLE1-to-partner and partner-to-ANKLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myeloid progenitor cell differentiation grouped by ANKLE1-low versus ANKLE1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKLE1→partner) and Y-score (partner→ANKLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of myeloid progenitor cell differentiation →	-0.269	-1.041	<.001	<.001	3	17
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.179	+2.578	<.001	<.001	3	13
BONE	rRNA metabolic process →	+0.101	+1.983	<.001	<.001	3	12
BONE	Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.139	+2.183	<.001	<.001	3	12
BONE	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.124	+1.826	<.001	<.001	3	12
BONE	Transcription initiation at RNA polymerase I promoter →	+0.157	+2.470	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,538 associations by consensus.

Regulation of myeloid progenitor cell differentiation by ANKLE1 expression — BREAST

Explore this box plot interactively →