ANKLE1

Across TCGA cell cohorts, ANKLE1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANKLE1-associated genes across cancer lineages are OR8B4, FAM25C, and MYBPC3. Each is linked with ANKLE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKLE1-to-partner and partner-to-ANKLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B4 grouped by ANKLE1-low versus ANKLE1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKLE1→partner) and Y-score (partner→ANKLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR8B4 →	+0.036	+4.906	<.001	.006	3	1
SKIN	FAM25C →	+0.853	+4.930	<.001	.001	3	1
LARGE_INTESTINE	MYBPC3 →	+0.034	+3.333	.002	.009	3	1
LARGE_INTESTINE	PTH2R →	+1.323	+3.716	<.001	.003	3	1
LARGE_INTESTINE	SAXO1 →	+0.041	+3.819	.002	.001	3	1
LARGE_INTESTINE	DNASE1L3 →	+0.072	+3.491	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR8B4 by ANKLE1 expression — OESOPHAGUS

Explore this box plot interactively →