ANKK1

Across TCGA patient cohorts, ANKK1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKK1-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and TAZ. Each is linked with ANKK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKK1-to-partner and partner-to-ANKK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ANKK1-low versus ANKK1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKK1→partner) and Y-score (partner→ANKK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.732	+2.178	.049	.035	3	3
UCEC	MEK1 →	+0.320	+1.662	.013	.011	3	2
COAD	TAZ →	+0.214	+2.195	.020	.034	3	2
UCEC	eEF2 →	+0.300	+1.362	.017	.037	3	2
UCEC	EGFR_pY1068 →	-0.234	-1.906	.008	.015	3	2
UCEC	Ku80 →	+0.200	+1.676	.016	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by ANKK1 expression — COAD

Explore this box plot interactively →