ANKIB1

Across TCGA patient cohorts, ANKIB1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKIB1-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and FASN. Each is linked with ANKIB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKIB1-to-partner and partner-to-ANKIB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ANKIB1-low versus ANKIB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKIB1→partner) and Y-score (partner→ANKIB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.540	+1.222	.004	.035	3	3
UCEC	C-Raf →	+0.177	+2.700	<.001	.005	3	3
UCEC	FASN →	+0.447	+1.765	<.001	.013	3	2
UCEC	FoxM1 →	+0.228	+2.817	.006	.001	3	2
UCEC	JNK2 →	+0.196	+1.687	.002	.013	3	2
UCEC	14-3-3_beta →	-0.072	-1.673	.026	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-7-cleavedD198 by ANKIB1 expression — UCEC

Explore this box plot interactively →