ANKHD1

Across TCGA patient cohorts, ANKHD1 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKHD1-associated genes across cancer lineages are MTND6P17, RAC1P8, and RNA5SP414. Each is linked with ANKHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKHD1-to-partner and partner-to-ANKHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND6P17 grouped by ANKHD1-low versus ANKHD1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKHD1→partner) and Y-score (partner→ANKHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MTND6P17 →	+0.233	+7.640	<.001	.009	3	2
SKCM	RAC1P8 →	+0.059	+7.816	<.001	.008	3	2
UCEC	RNA5SP414 →	+0.765	+3.255	<.001	.003	3	1
UCEC	RNA5SP411 →	+1.316	+3.130	.002	.003	3	1
UCEC	RNA5SP412 →	+0.849	+2.967	<.001	.007	3	1
UCEC	HNRNPCL3 →	+0.068	+3.193	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

MTND6P17 by ANKHD1 expression — BLCA

Explore this box plot interactively →