ANKHD1

Across TCGA cell cohorts, ANKHD1 mutation is significantly associated with the RNA expression of many other genes, with 184 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANKHD1-associated genes across cancer lineages are ADRA1A, IL36RN, and ABCD1. Each is linked with ANKHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKHD1-to-partner and partner-to-ANKHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADRA1A grouped by ANKHD1-low versus ANKHD1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKHD1→partner) and Y-score (partner→ANKHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ADRA1A →	+0.077	+3.722	.006	.007	3	2
LUNG_SCLC	IL36RN →	+0.161	+3.887	.001	.005	3	2
LARGE_INTESTINE	ABCD1 →	-0.961	-3.169	.008	.009	3	2
BREAST	RETNLB →	+0.044	+5.169	<.001	.005	3	2
CNS	PRAMEF10 →	+0.289	+4.754	<.001	.005	3	2
CNS	PRAMEF33 →	+0.432	+4.321	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 184 associations by consensus.

ADRA1A by ANKHD1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →