ANKFN1

Across TCGA pan-cancer cohorts, ANKFN1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ANKFN1 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ANKFN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ANKFN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and SCLC are the cancer types where ANKFN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.059	0.712	<.001	24	view →
UCEC	DFS	Median	All	0.962	0.616	.009	20	view →
SCLC	OS	Median	II,III,IV	0.192	0.645	.014	9	view →
LUSC	OS	Median	III,IV	0.505	0.684	.002	7	view →
PCPG	DFS	Median	All	0.104	0.904	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ANKFN1–HNSC (OS)

Open the HNSC breakdown →