ANKFN1

Across TCGA patient cohorts, ANKFN1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKFN1-associated genes across cancer lineages are Src_pY527, Smad1, and NF-kB-p65_pS536. Each is linked with ANKFN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKFN1-to-partner and partner-to-ANKFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by ANKFN1-low versus ANKFN1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKFN1→partner) and Y-score (partner→ANKFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Src_pY527 →	-0.376	-2.450	.031	.019	3	2
COAD	Smad1 →	+0.162	+2.195	.016	.034	3	2
SKCM	NF-kB-p65_pS536 →	-0.326	-1.584	.020	.018	3	2
SKCM	XBP1 →	+0.214	+1.906	.015	.014	3	2
SKCM	YAP →	+0.145	+3.338	.041	.004	3	2
UCEC	EGFR_pY1068 →	-0.248	-2.222	.007	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Src_pY527 by ANKFN1 expression — LUSC

Explore this box plot interactively →