ANKFN1

Across TCGA cell cohorts, ANKFN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,621 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ANKFN1-associated GO terms across cancer lineages are Intrinsic apoptotic signaling pathway, Response to topologically incorrect protein, and Cellular response to topologically incorrect protein. Each is linked with ANKFN1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ANKFN1-to-partner and partner-to-ANKFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intrinsic apoptotic signaling pathway grouped by ANKFN1-low versus ANKFN1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKFN1→partner) and Y-score (partner→ANKFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Intrinsic apoptotic signaling pathway →	+0.044	+0.314	.001	.004	3	6
PANCREAS	Response to topologically incorrect protein →	+0.085	+0.233	<.001	.001	2	7
PANCREAS	Cellular response to topologically incorrect protein →	+0.080	+0.243	.005	.006	2	7
BONE	Endoplasmic reticulum to cytosol transport →	+0.129	+0.487	<.001	<.001	3	5
BONE	Negative regulation of response to endoplasmic reticulum stress →	+0.111	+0.607	<.001	.006	3	5
PANCREAS	Cellular response to unfolded protein →	+0.095	+0.220	<.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,621 associations by consensus.

Intrinsic apoptotic signaling pathway by ANKFN1 expression — LARGE_INTESTINE

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