ANKEF1

Across TCGA patient cohorts, ANKEF1 mutation is significantly associated with the RNA expression of many other genes, with 3,191 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKEF1-associated genes across cancer lineages are SURF6P1, SAPCD2, and INSIG1. Each is linked with ANKEF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKEF1-to-partner and partner-to-ANKEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SURF6P1 grouped by ANKEF1-low versus ANKEF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKEF1→partner) and Y-score (partner→ANKEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SURF6P1 →	+0.113	+3.868	<.001	.003	3	3
UCEC	SAPCD2 →	+0.778	+2.465	<.001	<.001	3	3
UCEC	INSIG1 →	+0.707	+2.939	<.001	<.001	3	3
UCEC	ATAD3A →	+0.503	+2.432	<.001	<.001	3	3
UCEC	C1orf174 →	+0.361	+2.545	<.001	<.001	3	3
UCEC	PGAM5 →	+0.659	+2.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,191 associations by consensus.

SURF6P1 by ANKEF1 expression — COAD

Explore this box plot interactively →