ANKEF1

Across TCGA patient cohorts, ANKEF1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKEF1-associated genes across cancer lineages are TFRC, Cyclin-B1, and Notch1. Each is linked with ANKEF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKEF1-to-partner and partner-to-ANKEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ANKEF1-low versus ANKEF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKEF1→partner) and Y-score (partner→ANKEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.403	+2.459	.023	.018	3	3
UCEC	Cyclin-B1 →	+0.701	+2.201	<.001	<.001	3	3
STAD	Notch1 →	+0.241	+2.828	.008	.035	3	2
UCEC	eIF4E →	+0.217	+2.584	.002	<.001	2	3
UCEC	ACC1 →	+0.419	+3.713	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.427	-1.906	.004	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

TFRC by ANKEF1 expression — UCEC

Explore this box plot interactively →