ANK3

Across TCGA patient cohorts, ANK3 mutation is significantly associated with the total protein of many other genes, with 95 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ANK3-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and TFRC. Each is linked with ANK3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ANK3-to-partner and partner-to-ANK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ANK3-low versus ANK3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANK3→partner) and Y-score (partner→ANK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.965	+2.087	<.001	.004	3	5
STAD	eEF2 →	+0.377	+2.906	.001	.001	2	5
STAD	TFRC →	+0.896	+3.321	<.001	.009	2	5
STAD	Bap1-c-4 →	+0.423	+2.222	.002	.010	3	4
STAD	c-Kit →	-0.473	-2.906	<.001	.001	3	4
LUAD	Cyclin-B1 →	+0.532	+2.584	.014	.011	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

Caspase-7-cleavedD198 by ANK3 expression — COAD

Explore this box plot interactively →