ANK1

Across TCGA patient cohorts, ANK1 mutation is significantly associated with the total protein of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANK1-associated genes across cancer lineages are eEF2, beta-Catenin, and 14-3-3_beta. Each is linked with ANK1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ANK1-to-partner and partner-to-ANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ANK1-low versus ANK1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANK1→partner) and Y-score (partner→ANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eEF2 →	+0.303	+3.584	.021	.002	3	6
STAD	beta-Catenin →	+0.960	+3.169	.002	.018	3	5
LUSC	14-3-3_beta →	-0.126	-1.798	.003	.026	3	4
LUSC	4E-BP1 →	+0.339	+1.816	.018	.015	3	4
STAD	ACVRL1 →	-0.260	-3.321	.005	.009	3	4
STAD	Cyclin-E2 →	+0.130	+2.828	.027	.033	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

eEF2 by ANK1 expression — STAD

Explore this box plot interactively →