ANK1

Across TCGA cell cohorts, ANK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,749 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ANK1-associated GO terms across cancer lineages are Maintenance of apical/basal cell polarity, Maintenance of epithelial cell apical/basal polarity, and Regulation of intracellular transport. Each is linked with ANK1 in more than 15 cancer types. Because this analysis shows association rather than direction, both ANK1-to-partner and partner-to-ANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of apical/basal cell polarity grouped by ANK1-low versus ANK1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANK1→partner) and Y-score (partner→ANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Maintenance of apical/basal cell polarity →	-0.240	-2.654	<.001	.001	3	16
LUNG_NSCLC_LUSC	Maintenance of epithelial cell apical/basal polarity →	-0.240	-2.654	<.001	.001	3	16
LUNG_NSCLC_LUSC	Regulation of intracellular transport →	+0.053	+2.374	<.001	.001	3	8
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.110	+1.370	<.001	.002	2	9
BONE	Regulation of cell-substrate adhesion →	+0.136	+1.314	<.001	<.001	3	8
LIVER	Regulation of cardiac muscle adaptation →	+0.303	+1.683	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,749 associations by consensus.

Maintenance of apical/basal cell polarity by ANK1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →