ANK1

Across TCGA cell cohorts, ANK1 mutation is significantly associated with the RNA expression of many other genes, with 1,653 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANK1-associated genes across cancer lineages are PXYLP1, PRPF8, and CRLF3. Each is linked with ANK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANK1-to-partner and partner-to-ANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PXYLP1 grouped by ANK1-low versus ANK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANK1→partner) and Y-score (partner→ANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PXYLP1 →	+0.753	+2.628	.001	.002	3	3
LARGE_INTESTINE	PRPF8 →	+0.501	+3.237	.002	.003	3	3
LARGE_INTESTINE	CRLF3 →	+0.531	+2.628	.002	.002	3	3
LARGE_INTESTINE	RMI1 →	+0.665	+3.743	<.001	<.001	3	3
BLOOD_Leukemia	ARHGAP19 →	+0.824	+3.176	.002	.008	3	3
BLOOD_Leukemia	CCDC110 →	+0.444	+3.449	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,653 associations by consensus.

PXYLP1 by ANK1 expression — LARGE_INTESTINE

Explore this box plot interactively →