ANGPTL8

Across TCGA pan-cancer cohorts, ANGPTL8 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ANGPTL8’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ANGPTL8 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ANGPTL8 is over-expressed in tumor, although a few such as LSCC and CCRCC show the opposite, repressed pattern.

LSCC, CCRCC, and LUAD are the cancer types where ANGPTL8 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANGPTL8 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	−2.020	<.001	4	view →
CCRCC	All	All	−0.690	<.001	2	view →
LUAD	All	All	−0.454	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

ANGPTL8–LSCC

Open the LSCC breakdown →