ANGPTL8

Across TCGA patient cohorts, ANGPTL8 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,129 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ANGPTL8-associated GO terms across cancer lineages are Heparan sulfate proteoglycan catabolic process, ATP biosynthetic process, and Methylglyoxal metabolic process. Each is linked with ANGPTL8 in more than 18 cancer types. Because this analysis shows association rather than direction, both ANGPTL8-to-partner and partner-to-ANGPTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heparan sulfate proteoglycan catabolic process grouped by ANGPTL8-low versus ANGPTL8-high in KIRC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL8→partner) and Y-score (partner→ANGPTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Heparan sulfate proteoglycan catabolic process →	+0.051	+0.770	<.001	<.001	3	18
STAD	ATP biosynthetic process →	+0.048	+0.259	<.001	<.001	3	18
STAD	Methylglyoxal metabolic process →	+0.042	+0.314	<.001	<.001	3	18
STAD	Regulation of sphingolipid biosynthetic process →	+0.057	+0.309	<.001	<.001	3	17
ESCA	Microtubule-based protein transport →	+0.075	+0.319	<.001	.004	2	18
ESCA	Peptidyl-proline modification →	+0.048	+0.258	.001	.002	2	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,129 associations by consensus.

Heparan sulfate proteoglycan catabolic process by ANGPTL8 expression — KIRC

Explore this box plot interactively →