ANGPTL8

Across TCGA patient cohorts, ANGPTL8 mutation is significantly associated with the RNA expression of many other genes, with 167 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPTL8-associated genes across cancer lineages are LINC00518, SLC22A10, and PRR30. Each is linked with ANGPTL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL8-to-partner and partner-to-ANGPTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00518 grouped by ANGPTL8-low versus ANGPTL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL8→partner) and Y-score (partner→ANGPTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC00518 →	+0.234	+2.487	<.001	.006	3	1
UCEC	SLC22A10 →	+0.073	+2.574	<.001	.002	3	1
UCEC	PRR30 →	+0.210	+2.594	.004	.001	3	1
UCEC	KRTAP23-1 →	+0.217	+2.547	.003	.009	3	1
UCEC	SFMBT2 →	+0.564	+3.241	<.001	.009	3	1
UCEC	RNA5SP502 →	+0.502	+2.771	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 167 associations by consensus.

LINC00518 by ANGPTL8 expression — UCEC

Explore this box plot interactively →