ANGPTL8

Across TCGA patient cohorts, ANGPTL8 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPTL8-associated genes across cancer lineages are Transglutaminase, MSH6, and MSH2. Each is linked with ANGPTL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL8-to-partner and partner-to-ANGPTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transglutaminase grouped by ANGPTL8-low versus ANGPTL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL8→partner) and Y-score (partner→ANGPTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Transglutaminase →	+0.787	+3.000	.002	.037	3	1
UCEC	MSH6 →	-0.831	-3.000	<.001	.037	2	1
UCEC	MSH2 →	-0.650	-3.000	<.001	.037	1	1
UCEC	AMPK_pT172 →	+0.695	+3.013	.003	.019	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Transglutaminase by ANGPTL8 expression — UCEC

Explore this box plot interactively →