ANGPTL8

Across TCGA cell cohorts, ANGPTL8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,037 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible ANGPTL8-associated GO terms across cancer lineages are Skeletal system morphogenesis, Negative regulation of microtubule depolymerization, and Platelet formation. Each is linked with ANGPTL8 in more than 4 cancer types. Because this analysis shows association rather than direction, both ANGPTL8-to-partner and partner-to-ANGPTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Skeletal system morphogenesis grouped by ANGPTL8-low versus ANGPTL8-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL8→partner) and Y-score (partner→ANGPTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Skeletal system morphogenesis →	+0.041	+0.086	.005	.005	2	5
CNS	Negative regulation of microtubule depolymerization →	+0.056	+0.098	.003	.001	3	4
KIDNEY	Platelet formation →	+0.099	+0.107	.002	.003	3	4
KIDNEY	Copper ion homeostasis →	+0.058	+0.106	.008	.008	2	5
BLOOD_Leukemia	Negative regulation of insulin receptor signaling pathway →	+0.058	+0.057	<.001	.006	3	4
OESOPHAGUS	Mycotoxin metabolic process →	-0.156	-0.090	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,037 associations by consensus.

Skeletal system morphogenesis by ANGPTL8 expression — STOMACH

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