ANGPTL7

Across TCGA patient cohorts, ANGPTL7 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPTL7-associated genes across cancer lineages are PCNA, EGFR_pY1068, and HER2_pY1248. Each is linked with ANGPTL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL7-to-partner and partner-to-ANGPTL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ANGPTL7-low versus ANGPTL7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL7→partner) and Y-score (partner→ANGPTL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.266	+2.000	.003	.030	3	2
UCEC	EGFR_pY1068 →	-0.310	-2.906	.003	.001	3	1
UCEC	HER2_pY1248 →	-0.228	-2.906	.044	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.174	-1.687	.014	.044	3	1
UCEC	MAPK_pT202_Y204 →	-0.430	-2.000	.031	.030	3	1
UCEC	MEK1 →	+0.387	+2.459	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PCNA by ANGPTL7 expression — UCEC

Explore this box plot interactively →