ANGPTL7

Across TCGA cell cohorts, ANGPTL7 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANGPTL7-associated genes across cancer lineages are AVP, SMR3B, and CELA2B. Each is linked with ANGPTL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL7-to-partner and partner-to-ANGPTL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by ANGPTL7-low versus ANGPTL7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL7→partner) and Y-score (partner→ANGPTL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.048	+3.217	<.001	.006	3	1
LARGE_INTESTINE	SMR3B →	+0.545	+3.297	.008	.002	3	1
LARGE_INTESTINE	CELA2B →	+0.061	+4.009	<.001	<.001	3	1
LARGE_INTESTINE	GRIFIN →	+0.071	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

AVP by ANGPTL7 expression — LARGE_INTESTINE

Explore this box plot interactively →